最高學歷：高雄醫學大學醫學博士
現任經歷：慈濟大學醫學科學研究所教授兼眼暨視覺科教授,花蓮慈濟醫院眼科研究中心主任
研究領域： 1.神經保護 2.動物模式 3.再生醫學 4.神經眼科 5.轉譯醫學
電話：03-8561825 分機 12718, 12112
電子信箱： rktsai@mail.tcu.edu.tw
近五年指導研究生名單：
1.黃子倫，醫學科學研究所(已畢業)
2.阮吳黎明英，醫學科學研究所 (已畢業)
3. Rupendra Shrestha，醫學科學研究所 (已畢業)
4. 黃晉德，醫學科學研究所(己畢業)
5. 李岳章，轉譯醫學博士學位學程
6. 徐巧玲，醫學科學研究所
近五年著作：
1. Huang TL, Wang JK , Chang PY, Hsu YR, Lin CH, Lin KH, Tsai RK* (2022, Jul). Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives. International Journal of Molecular Sciences, 2022, 23, 7908. https://doi.org/10.3390/ijms23147908. (SCI, 69/296,BIOCHEMISTRY & MOLECULAR BIOLOGY). MOST 110-2221-E-1550-013. 本人為通訊作者.
2. Wen YT, Jhou BY, Hsu JH, Fu HI, Chen YL, Shih YC, Chen CC, Tsai RK*
(2022, Feb). Neuroprotective Effects of Cordyceps cicadae (Ascomycetes) Mycelium Extract in the Rat Model of Optic Nerve Crush. International Journal of Medicinal Mushrooms, 24(2):41?–?48. (SCI, 242/357,PHARMACOLOGY & PHARMACY). 本人為通訊作者.
3. Desai TD ,Wen YT, Daddam JR, Cheng F, Chen CC, Pan CL, Lin KL, Tsai RK* (2022, Jan). Long term therapeutic effects of icariin-loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP-β/GCSF/
noncanonical NF-κB axis. Bioengineering & Translational Medicine, Bioeng Transl Med. 2022;e10289. https://doi.org/10.1002/btm2.10289. (SCI, 8/106,ENGINEERING, BIOMEDICAL). 花蓮慈濟醫院: TCRD107-30. 本人為通訊作者.
4. Huang CT, Wen YT, Desai TD, Tsai RK*. (2021, Dec). Intravitreal injection of Long-acting pegylated granulocyte colony-stimulating factor provides neuroprotective effects via antioxidant responses in a rat model of traumatic optic neuropathy.. Antioxidants, 10(12):1934. (SCI, 54/311,BIOCHEMISTRY & MOLECULAR BIOLOGY). 本人為通訊作者.
5. Kang EY, Liu PK,Wen YT, Quin PMJ, Levi SR, Wang NK, Tsai RK*. (2021, Dec). Role of oxidative stress in ocular diseases associated with retinal ganglion cells degeneration.. Antioxidants, 10(12):1948. 本人為通訊作者.
6. Wen YT, Huang CW, Liu CP, Chen CH, Tu CM, Hwang CS , Chen YH, Chen WR, Lin KL, Ho YC, Chen TC, Tsai RK* (2021, May). Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammator yActions. Invest Ophthalmol Vis Sci, 3;62(6):21. (SCI, 10/60, OPHTHALMOLOGY ). 本人為通訊作者.
7. Wen YT, Ho YC, Lee YC, Ding DC, Liu PK, Tsai RK* (2021, Feb). The Benefits and Hazards of Intravitreal Mesenchymal Stem Cell (MSC) Based-Therapies in the Experimental Ischemic Optic Neuropathy. International Journal of Molecular Sciences, 2021, 22, 2117. https://doi.org/10.3390/ijms22042117. (SCI, 74/297,BIOCHEMISTRY & MOLECULAR BIOLOGY). 花蓮慈濟醫院: TCRD107-69 . 本人為通訊作者.
8. Liu PK, Chang YC, Tai MH, Tsai RK, Chong IW, Wu KY, Wu WC, Hsu CY, Tsai MJ (2020, Oct). THE ASSOCIATION BETWEEN CENTRAL SEROUS CHORIORETINOPATHY AND SLEEP APNEA: A Nationwide Population-Based Study. , 40(10):2034-2044. (SCI, 8/60,OPHTHALMOLOGY ).
9. Shrestha R, Wen YT, Tsai RK* (2020, Sep). Effective Differentiation and Biological Characterization of Retinal Pigment Epithelium Derived from Human Induced Pluripotent Stem Cells. Current Eye Research, 45(9):1155-1167. (SCI, 35/60,OPHTHALMOLOGY). 花蓮慈濟醫院: TCMMP104-05-01. 本人為通訊作者.
10. Liu PK , Wen YT , Lin W , Kapupara K , Tai M , Tsai RK * (2020, Jun). Neuroprotective effects of lowdose G-CSF plus meloxicam in a rat model of anterior ischemic optic neuropathy. Scientific Reports, 25;10(1):10351. (SCI, 15/69,MULTIDISCIPLINARY SCIENCES). MOST 103-2314-B-303-007-MY3. 本人為通訊作者.
11. Huang TL†, Wen YT†, Ho YC, Wang JK, Lin KH, Tsai RK* (2020, Jan). Algae Oil Treatment Protects Retinal Ganglion Cells (RGCs) via ERK Signaling Pathway in Experimental Optic Nerve Ischemia. Marine Drugs, 27;18(2):83. (SCI, 15/61,CHEMISTRY, MEDICINAL). 亞東紀念醫院: FEMH-2018-C-028. 本人為通訊作者.
12. Lin WN†, Kapupara K†, Wen YT , Chen YH ,Pan IH, Tsai RK* (2020, Jan). Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia. Marine Drugs, 28;18(2):85. (SCI, 15/61,CHEMISTRY, MEDICINAL). 花蓮慈濟醫院: TCRD107-30. 本人為通訊作者.
13. Shresthaa R, Wen YT, Tsai RK* (2019, Dec). Generation of hiPSC line TCIERi001-A from normal human epidermal keratinocytes. Stem Cell Research, 41(https://doi.org/10.1016/j.scr.2019.101590). (SCI, 34/162,BIOTECHNOLOGY & APPLIED MICROBIOLOGY). 花蓮慈濟醫院: TCMMP104-05-01 . 本人為通訊作者.
14. Shrestha R, Wen YT, Tsai RK * (2019, Sep). Induced pluripotent stem cells and derivative photoreceptor precursors as therapeutic cells for retinal degenerations. Tzu Chi Medical Journal, 30;32(2): 101–112. 花蓮慈濟醫院: TCMMP104-05-01 . 本人為通訊作者.
15. Nguyen Ngo Le MA ,Wen YT ,Ho YC ,Kapupara K ,Tsai RK* (2019, Aug). Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti- Inflammatory Actions. Investigative Ophthalmology & Visual Science, 60 (10),3481-3491. (SCI, 9/59,OPHTHALMOLOGY ). MOST 103-2314-B-303-007-MY3. 本人為通訊作者.
16. Wen YT, Zhang JR, Kapupara K , Tsai RK* (2019, Aug). mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction intraumatic optic nerve injury. Experimental & Molecular Medicine, 13;51(8):1-11. doi: 10.1038/s12276-019-0298-z.. (SCI, 53/298,MEDICINE, RESEARCH & EXPERIMENTAL). MOST 103-2314-B-303-007-MY3. 本人為通訊作者.
17. Lee YC, Tsai RK* (2019, Jul). Risk of Stroke After Nonarteritic Anterior Ischemic Optic Neuropathy. American Journal of Ophthalmology, 203:118-119. (SCI, 6/60,OPHTHALMOLOGY). 本人為通訊作者. Letter to Editor.
18. Kishan K , Huang TL , Wen YT , Huang SP , Tsai RK* (2019, Apr). Optic nerve head width and retinal nerve fiber layer changes are proper indexes for validating the successful induction of experimental anterior ischemic optic neuropathy. Experimental Eye Research, 181,105-111. (SCI, 14/59,OPHTHALMOLOGY). MOST 104-2314-B-320-002. 本人為通訊作者.
19. Shrestha R , Wen YT , Ding DC , Tsai RK* (2019, Jan). Aberrant hiPSCs-Derived from Human Keratinocytes Differentiates into 3D Retinal Organoids that Acquire Mature Photoreceptors. Cells, 8(1), 36,1-23. (SCI, 55/190,CELL BIOLOGY – SCIE). 花蓮慈濟醫院: TCMMP104-05-01. 本人為通訊作者.
20. Ding DC, Wen YT , Tsai RK* (2017, Dec). Pigment epithelium-derived factor from ARPE19 promotes proliferation and inhibits apoptosis of human umbilical mesenchymal stem cells in serum-free medium. Experimental & Molecular Medicine , 15;49(12):e411. (SCI, 13/128/RESEARCH & EXPERIMENTAL). 花蓮慈濟醫院: TCRDI 104-01-03. 本人為通訊作者.
21. Kuo YC, Chen N, Tsai RK* (2017, Dec). Acute Zonal Occult Outer Retinopathy (AZOOR): a case report of vision improvement after intravitreal injection of Ozurdex. BMC Ophthalmology, 17(236). (SCI, 64.40%,OPHTHALMOLOGY). 本人為通訊作者.
22. Kapupara K, Wen YT, Tsai RK , Huang SP (2017, Nov). Soluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury. Cell Death & Disease, 16;8(11):e3172. (SCI, 41/190,CELL BIOLOGY). MOST 104-2314-B-320-002-MY1.
23. Chang YH, Liu HW, Chu TY, Wen YT, Tsai RK , Ding DC (2017, Jun). Cisplatin-Impaired Adipogenic Differentiation of Adipose Mesenchymal Stem Cells. Cell & Tissue Engineering, 9,26(6),1077-1087. (SCI, 13/21,CELL TRANSPLANTATION). 花蓮慈濟醫院: TCRD104-07.
24. Huang TL, Wen YT, Chang CH, Chang SW, Lin KH , Tsai RK* (2017, Mar). Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION). Investigative Ophthalmology & Visual Science, 58(3),1628-1636. (SCI, 11/59,OPHTHALMOLOGY). 亞東醫院: FEMH-2016-C-034. 本人為通訊作者.
25. T. Georgiou, Wen YT , Chang CH , P. Kolovos, M. Kalogerou, E. Prokopiou, A. Neokleous, Huang CT , Tsai RK* (2017, Mar). Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids in a Rat Model of Anterior Ischemic Optic Neuropathy. Investigative Ophthalmology & Visual Science, 58(3),1603-1611. (SCI, 11/59,OPHTHALMOLOGY). 本人為通訊作者.
26. TSAI RK* (2017, Mar). EPLY: Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. American Journal of Ophthalmology, 175,214. (SCI, 5/56,OPHTHALMOLOGY). 花蓮慈濟醫院: TCRD103-21. 本人為第一作者、通訊作者.
27. Huang TL, Wang JK, Pang CY, Tsai RK* (2017). Leber’s Hereditary Optic Neuropathy Associated with the m.10197G>A Mutation. Journal of Clinical & Experimental Ophthalmology, 8(4). 本人為通訊作者.